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Polymorphism in Pharmaceutical Solids

Polymorphism in Pharmaceutical Solids PDF Author: Harry G. Brittain
Publisher: CRC Press
ISBN: 1420073222
Category : Medical
Languages : en
Pages : 656

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Book Description
Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism a

Polymorphism in Pharmaceutical Solids

Polymorphism in Pharmaceutical Solids PDF Author: Harry G. Brittain
Publisher: CRC Press
ISBN: 1420073222
Category : Medical
Languages : en
Pages : 656

View

Book Description
Using clear and practical examples, Polymorphism of Pharmaceutical Solids, Second Edition presents a comprehensive examination of polymorphic behavior in pharmaceutical development that is ideal for pharmaceutical development scientists and graduate students in pharmaceutical science. This edition focuses on pharmaceutical aspects of polymorphism a

Polymorphism in the Pharmaceutical Industry

Polymorphism in the Pharmaceutical Industry PDF Author: Rolf Hilfiker
Publisher: John Wiley & Sons
ISBN: 3527340408
Category : Science
Languages : en
Pages : 512

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Book Description
"Polymorphism in the Pharmaceutical Industry - Solid Form and Drug Development" highlights the relevance of polymorphism in modern pharmaceutical chemistry, with a focus on quality by design (QbD) concepts. It covers all important issues by way of case studies, ranging from properties and crystallization, via thermodynamics, analytics and theoretical modelling right up to patent issues. As such, the book underscores the importance of solid-state chemistry within chemical and pharmaceutical development. It emphasizes why solid-state issues are important, the approaches needed to avoid problems and the opportunities offered by solid-state properties. The authors include true polymorphs as well as solvates and hydrates, while providing information on physicochemical properties, crystallization thermodynamics, quantum-mechanical modelling, and up-scaling. Important analytical tools to characterize solid-state forms and to quantify mixtures are summarized, and case studies on solid-state development processes in industry are also provided. Written by acknowledged experts in the field, this is a high-quality reference for researchers, project managers and quality assurance managers in pharmaceutical, agrochemical and fine chemical companies as well as for academics and newcomers to organic solid-state chemistry.

Polymorphism

Polymorphism PDF Author: Rolf Hilfiker
Publisher: John Wiley & Sons
ISBN: 3527607722
Category : Science
Languages : en
Pages : 433

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Book Description
Edited by one of the leading experts in the field, this handbook emphasizes why solid-state issues are important, which approaches should be taken to avoid problems and exploit the opportunities offered by solid state properties in the pharmaceutical and agricultural industries. With its practical approach, this is at once a guideline for development chemists just entering the field as well as a high-quality source of reference material for specialists in the pharmaceutical and chemical industry, structural chemists, physicochemists, crystallographers, inorganic chemists, and patent departments.

Characterization and Control of Polymorphism in Pharmaceutical Solids

Characterization and Control of Polymorphism in Pharmaceutical Solids PDF Author: Mahmoud Mirmehrabi
Publisher:
ISBN:
Category :
Languages : en
Pages : 592

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Polymorphism and phase transformations in pharmaceutical solids

Polymorphism and phase transformations in pharmaceutical solids PDF Author:
Publisher:
ISBN:
Category :
Languages : en
Pages :

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Solid-State Properties of Pharmaceutical Materials

Solid-State Properties of Pharmaceutical Materials PDF Author: Stephen R. Byrn
Publisher: John Wiley & Sons
ISBN: 1118145305
Category : Science
Languages : en
Pages : 432

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Book Description
Solid-State Properties of Pharmaceutical Materials -- Contents -- Preface -- Acknowledgments -- 1 Solid-State Properties and Pharmaceutical Development -- 1.1 Introduction -- 1.2 Solid-State Forms -- 1.3 ICH Q6A Decision Trees -- 1.4 "Big Questions" for Drug Development -- 1.5 Accelerating Drug Development -- 1.6 Solid-State Chemistry in Preformulation and Formulation -- 1.7 Learning Before Doing and Quality by Design -- 1.8 Performance and Stability in Pharmaceutical Development -- 1.9 Moisture Uptake -- 1.10 Solid-State Reactions -- 1.11 Noninteracting Formulations: Physical Characterizations -- References -- 2 Polymorphs -- 2.1 Introduction -- 2.2 How Are Polymorphs Formed? -- 2.3 Structural Aspect of Polymorphs -- 2.3.1 Configurational Polymorphs -- 2.3.2 Conformational Polymorphs -- 2.4 Physical, Chemical, and Mechanical Properties -- 2.4.1 Solubility -- 2.4.2 Chemical Stability -- 2.4.3 Mechanical Properties -- 2.5 Thermodynamic Stability of Polymorphs -- 2.5.1 Monotropy and Enantiotropy -- 2.5.2 Burger and Rambergers Rules -- 2.5.3 vant Hoff Plot -- 2.5.4 DG/Temperature Diagram -- 2.6 Polymorph Conversion -- 2.6.1 Solution-Mediated Transformation -- 2.6.2 Solid-State Conversion -- 2.7 Control of Polymorphs -- 2.8 Polymorph Screening -- 2.9 Polymorph Prediction -- References -- 3 Solvates and Hydrates -- 3.1 Introduction -- 3.2 Pharmaceutical Importance of Hydrates -- 3.3 Classification of Pharmaceutical Hydrates -- 3.4 Water Activity -- 3.5 Stoichiometric Hydrates -- 3.6 Nonstoichiometric Hydrates -- 3.7 Hydration/Dehydration -- 3.8 Preparation and Characterization of Hydrates and Solvates -- References -- 4 Pharmaceutical Salts -- 4.1 Introduction -- 4.2 Importance of Pharmaceutical Salts -- 4.3 Weak Acid, Weak Base, and Salt -- 4.4 pH-Solubility Profiles of Ionizable Compounds

Handbook of Pharmaceutical Salts Properties, Selection, and Use

Handbook of Pharmaceutical Salts Properties, Selection, and Use PDF Author: P. Heinrich Stahl
Publisher: John Wiley & Sons
ISBN: 9783906390581
Category : Science
Languages : en
Pages : 374

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Book Description
This comprehensive up-to-date guide and information source is an instructive companion for all scientists involved in research and development of drugs and, in particular, of pharmaceutical dosage forms. The editors have taken care to address every conceivable aspect of the preparation of pharmaceutical salts and present the necessary theoretical foundations as well as a wealth of detailed practical experience in the choice of pharmaceutically active salts. Altogether, the contributions reflect the multidisciplinary nature of the science involved in selection of suitable salt forms for new drug products.

Chirality in Drug Design and Development

Chirality in Drug Design and Development PDF Author: Indra K. Reddy
Publisher: CRC Press
ISBN: 0824751094
Category : Science
Languages : en
Pages : 1200

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Book Description
Covering every essential element in the development of chiral products, this reference provides a solid overview of the formulation, biopharmaceutical characteristics, and regulatory issues impacting the production of these pharmaceuticals. It supports researchers as they evaluate the pharmacodynamic, pharmacokinetic, and toxicological characteristics of specific enantiomers and chiral drug compounds and addresses in one convenient reference all the major challenges pertaining to drug chirality that have been neglected in the literature. Chirality in Drug Design and Development collects the latest studies from an interdisciplinary team of experts on chiral drug design.

Handbook of Pharmaceutical Analysis

Handbook of Pharmaceutical Analysis PDF Author: Lena Ohannesian
Publisher: CRC Press
ISBN: 0824741943
Category : Medical
Languages : en
Pages : 608

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Book Description
Exploring the analysis of pharmaceuticals, including polymorphic forms, this book discusses regulatory requirements in pharmaceutical product development and pharmaceutical testing. It covers methods of drug separation and procedures such as capillary electrophoresis for chromatographic separation of molecules. Additional topics include drug formulation analysis using vibrational and magnetic resonance spectroscopy and identification of drug metabolites and decomposition products using such techniques as mass spectrometry. The book provides more than 300 tables, equations, drawings, and photographs, and convenient, easy-to-use indices, facilitating quick access to each topic.

Polymorphism and Phase Transformations in Pharmaceutical Solids

Polymorphism and Phase Transformations in Pharmaceutical Solids PDF Author: Katarzyna Anna Solanko
Publisher:
ISBN:
Category :
Languages : en
Pages :

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