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Patient-Specific Modeling of the Cardiovascular System

Patient-Specific Modeling of the Cardiovascular System PDF Author: Roy C.P. Kerckhoffs
Publisher: Springer
ISBN: 9781441966902
Category : Science
Languages : en
Pages : 240

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Book Description
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Patient-Specific Modeling of the Cardiovascular System

Patient-Specific Modeling of the Cardiovascular System PDF Author: Roy C.P. Kerckhoffs
Publisher: Springer
ISBN: 9781441966902
Category : Science
Languages : en
Pages : 240

View

Book Description
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Patient-Specific Modeling of the Cardiovascular System

Patient-Specific Modeling of the Cardiovascular System PDF Author: Roy C.P. Kerckhoffs
Publisher: Springer Science & Business Media
ISBN: 1441966919
Category : Science
Languages : en
Pages : 240

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Book Description
Peter Hunter Computational physiology for the cardiovascular system is entering a new and exciting phase of clinical application. Biophysically based models of the human heart and circulation, based on patient-specific anatomy but also informed by po- lation atlases and incorporating a great deal of mechanistic understanding at the cell, tissue, and organ levels, offer the prospect of evidence-based diagnosis and treatment of cardiovascular disease. The clinical value of patient-specific modeling is well illustrated in application areas where model-based interpretation of clinical images allows a more precise analysis of disease processes than can otherwise be achieved. For example, Chap. 6 in this volume, by Speelman et al. , deals with the very difficult problem of trying to predict whether and when an abdominal aortic aneurysm might burst. This requires automated segmentation of the vascular geometry from magnetic re- nance images and finite element analysis of wall stress using large deformation elasticity theory applied to the geometric model created from the segmentation. The time-varying normal and shear stress acting on the arterial wall is estimated from the arterial pressure and flow distributions. Thrombus formation is identified as a potentially important contributor to changed material properties of the arterial wall. Understanding how the wall adapts and remodels its material properties in the face of changes in both the stress loading and blood constituents associated with infl- matory processes (IL6, CRP, MMPs, etc.

Functional Imaging and Modeling of the Heart

Functional Imaging and Modeling of the Heart PDF Author: Hans van Assen
Publisher: Springer
ISBN: 3319203096
Category : Computers
Languages : en
Pages : 487

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Book Description
This book constitutes the refereed proceedings of the 8th International Conference on Functional Imaging and Modeling of the Heart, held in Maastricht, The Netherlands, in June 2015. The 54 revised full papers were carefully reviewed and selected from 72 submissions. The focus of the papers is on following topics: function; imaging; models of mechanics; and models of electrophysiology.

Patient-Specific Computational Modeling

Patient-Specific Computational Modeling PDF Author: Begoña Calvo Lopez
Publisher: Springer Science & Business Media
ISBN: 9400745524
Category : Technology & Engineering
Languages : en
Pages : 193

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Book Description
This book addresses patient-specific modeling. It integrates computational modeling, experimental procedures, imagine clinical segmentation and mesh generation with the finite element method (FEM) to solve problems in computational biomedicine and bioengineering. Specific areas of interest include cardiovascular problems, ocular and muscular systems and soft tissue modeling. Patient-specific modeling has been the subject of serious research over the last seven years and interest in the area is continually growing and this area is expected to further develop in the near future.

Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies

Patient-specific Hemodynamic Computations: Application to Personalized Diagnosis of Cardiovascular Pathologies PDF Author: Lucian Mihai Itu
Publisher: Springer
ISBN: 3319568531
Category : Medical
Languages : en
Pages : 227

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Book Description
Hemodynamic computations represent a state-of-the-art approach for patient-specific assessment of cardiovascular pathologies. The book presents the development of reduced-order multiscale hemodynamic models for coronary artery disease, aortic coarctation and whole body circulation, which can be applied in routine clinical settings for personalized diagnosis. Specific parameter estimation frameworks are introduced for calibrating the parameters of the models and high performance computing solutions are employed to reduce their execution time. The personalized computational models are validated against patient-specific measurements. The book is written for scientists in the field of biomedical engineering focusing on the cardiovascular system, as well as for research-oriented physicians in cardiology and industrial players in the field of healthcare technologies.

Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic

Mathematical Modeling of Cardiovascular Systems: From Physiology to the Clinic PDF Author: Julius Guccione
Publisher: Frontiers Media SA
ISBN: 2889633233
Category :
Languages : en
Pages :

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Book Description


3-Dimensional Modeling in Cardiovascular Disease

3-Dimensional Modeling in Cardiovascular Disease PDF Author: Evan M. Zahn
Publisher: Elsevier Health Sciences
ISBN: 0323653928
Category : Medical
Languages : en
Pages : 214

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Book Description
Written by physicians and surgeons, imaging specialists, and medical technology engineers, and edited by Dr. Evan M. Zahn of the renowned Cedars-Sinai Heart Institute, this concise, focused volume covers must-know information in this new and exciting field. Covering everything from the evolution of 3D modeling in cardiac disease to the various roles of 3D modeling in cardiology to cardiac holography and 3D bioprinting, 3-Dimensional Modeling in Cardiovascular Disease is a one-stop resource for physicians, cardiologists, radiologists, and engineers who work with patients, support care providers, and perform research. Provides history and context for the use of 3D printing in cardiology settings, discusses how to use it to plan and evaluate treatment, explains how it can be used as an education resource, and explores its effectiveness with medical interventions. Presents specific uses for 3D modeling of the heart, examines whether it improves outcomes, and explores 3D bioprinting. Consolidates today’s available information and guidance into a single, convenient resource.

Functional Imaging and Modeling of the Heart

Functional Imaging and Modeling of the Heart PDF Author: Dimitris N. Metaxas
Publisher: Springer
ISBN: 3642210287
Category : Computers
Languages : en
Pages : 439

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Book Description
This book constitutes the proceedings of the 6th International Conference on Functional Imaging and Modeling of the Heart, held in New York City, NY, USA in May 2011. The 24 revised full papers presented together with 29 revised poster papers were carefully reviewed and selected from about 120 initial submissions. The contributions feature current research and development efforts in the fields of cardiovascular modeling, physiology, and image-based analysis, at a range of scales and imaging methods. Topics addresses are such as imaging, signal and image processing, applied mathematics, biomedical engineering and computer science; biologically oriented fields such as cardiac physiology and biology; as well as clinical issues such as cardiology, radiology and surgery, with a common interest in the heart.

Modeling the Heart and the Circulatory System

Modeling the Heart and the Circulatory System PDF Author: Alfio Quarteroni
Publisher: Springer
ISBN: 3319052306
Category : Mathematics
Languages : en
Pages : 238

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Book Description
The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. The contributions cover a wide range of topics, from the preprocessing of clinical data to the development of mathematical equations, their numerical solution, and both in-vivo and in-vitro validation. They discuss the flow in the systemic arterial tree and the complex electro-fluid-mechanical coupling in the human heart. Many examples of patient-specific simulations are presented. This book is addressed to all scientists interested in the mathematical modeling and numerical simulation of the human cardiocirculatory system.

Mathematical and Numerical Modeling of the Cardiovascular System and Applications

Mathematical and Numerical Modeling of the Cardiovascular System and Applications PDF Author: Daniele Boffi
Publisher: Springer
ISBN: 3319966499
Category : Mathematics
Languages : en
Pages : 243

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Book Description
The book comprises contributions by some of the most respected scientists in the field of mathematical modeling and numerical simulation of the human cardiocirculatory system. It covers a wide range of topics, from the assimilation of clinical data to the development of mathematical and computational models, including with parameters, as well as their efficient numerical solution, and both in-vivo and in-vitro validation. It also considers applications of relevant clinical interest. This book is intended for graduate students and researchers in the field of bioengineering, applied mathematics, computer, computational and data science, and medicine wishing to become involved in the highly fascinating task of modeling the cardiovascular system.